Thesis
Engineering the electron relay in [FeFe] hydrogenase: step-wise truncation of the iron-sulfur cluster motifs in the F-domain
- Abstract:
-
Iron-sulfur (FeS) clusters play a crucial role in facilitating electron transfer within metalloenzymes, ensuring efficient catalysis by mediating electron flow between the protein surface and buried active sites. This study explores the engineering of electron relays in a highly efficient H2-producing enzyme, the [FeFe] hydrogenase from C. acetobutylicum (CaHydA1), which contains five iron-sulfur clusters, by a systematic truncation of the FeS clusters in the F...
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Authors
Contributors
+ Morra, S
- Role:
- Contributor
+ Rodriguez-Macia, P
- Role:
- Contributor
+ Vincent, K
- Institution:
- University of Oxford
- Division:
- MPLS
- Department:
- Chemistry
- Role:
- Supervisor
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Subjects:
- Deposit date:
-
2025-04-01
Terms of use
- Copyright holder:
- Tin Pou Lai
- Copyright date:
- 2025
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