Code and data for the paper Influence of correlated antigen presentation on T-cell negative selection in the thymus

Name: Code and data for the paper Influence of correlated antigen presentation on T-cell negative selection in the thymus
Published: 2018-01-01T00:00:00Z
License: https://ora.ox.ac.uk/terms_of_use

Chapman, S

Documentation:: Mathematica notebooks and accompanying data files which will generate the figures in the paper

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APA Style

Chapman, S. (2018). Code and data for the paper Influence of correlated antigen presentation on T-cell negative selection in the thymus. University of Oxford.

MLA Style

Chapman, S. Code and Data for the Paper Influence of Correlated Antigen Presentation on T-Cell Negative Selection in the Thymus. University of Oxford, 2018.

Chicago Style

Chapman, S. 2018. Code and Data for the Paper Influence of Correlated Antigen Presentation on T-Cell Negative Selection in the Thymus. University of Oxford.
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Authors/Creators

+ Chapman, S More by this author/creator

Institution:: University of Oxford
Division:: MPLS
Department:: Mathematical Institute
Role:: Creator

+ Wellcome Trust More from this funder

Grant:: 105045/Z/14/Z

Publisher:: University of Oxford
Publication date:: 2018
DOI:: 10.5287/bodleian:zryr1ZmmN

Pubs id:: 1480870
UUID:: uuid:831b5b9a-0c46-4a06-a40f-5461347340c2
Local pid:: pubs:1480870
Deposit date:: 2018-10-23
ARK identifier:: ark:/29072/ora_831b5b9a0c464a06a40f5461347340c2

Related item:: Influence of correlated antigen presentation on T-cell negative selection in the thymus
Description:: The thymus is the primary organ for the generation of naive T cells, a key component of the immune system. Tolerance of T cells to self is achieved primarily in the thymic medulla, where immature T cells (thymocytes) sample self-peptides presented by medullary thymic epithelial cells (mTECs). A sufficiently strong interaction activates the thymocytes leading to negative selection. A key question of current interest is whether there is any structure in the manner in which mTECs present peptides: can any mTEC present any peptide at any time, or are there particular patterns of correlated peptide presentation? We investigate this question using a mathematical model of negative selection. We find that correlated patterns of peptide presentation may be advantageous in negatively selecting low-degeneracy thymocytes (that is, those thymocytes which respond to relatively few peptides). We also quantify the probability that an auto-reactive thymocyte exits the thymus before it encounters a cognate antigen. The results suggest that heterogeneity of gene co-expression in mTECs has an effect on the probability of escape of autoreactive thymocytes.

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Code and data for the paper Influence of correlated antigen presentation on T-cell negative selection in the thymus

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