Journal article icon

Journal article

Force-induced rupture of a DNA duplex: from fundamentals to force sensors

Abstract:

The rupture of double-stranded DNA under stress is a key process in biophysics and nanotechnology. In this article, we consider the shear-induced rupture of short DNA duplexes, a system that has been given new importance by recently designed force sensors and nanotechnological devices. We argue that rupture must be understood as an activated process, where the duplex state is metastable and the strands will separate in a finite time that depends on the duplex length and the force applied. Thu...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

Actions


Access Document


Publisher copy:
10.1021/acsnano.5b04726

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Physical and Theoretical Chem
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Rudolf Peierls Centre for Theoretical Physics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Physical and Theoretical Chem
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Rudolf Peierls Centre for Theoretical Physics
Role:
Author
More from this funder
Funding agency for:
Ouldridge, TE
Engineering and Physical Sciences Research Council More from this funder
Publisher:
American Chemical Society Publisher's website
Journal:
ACS Nano Journal website
Volume:
9
Issue:
12
Pages:
11993–12003
Publication date:
2015-11-05
DOI:
EISSN:
1936-086X
ISSN:
1936-0851
URN:
uuid:82f0ac0f-cfdb-41a4-9cf5-f32fb8afa7d9
Source identifiers:
578809
Local pid:
pubs:578809

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP