A recently developed allograft system for the generation of a cell-mediated response in tissue culture was applied to an analysis of the cells involved in that response. Lymphoid cells from CBA mice (H-2k) were immunized in vitro with mitomycin-treated BALB/c (H-2d) spleen cells and the cell-mediated response measured by lysis of 51Cr-labeled P815 mastocytoma cells (H-2d). It was found that in mouse spleen the precursor of cytotoxic lymphocytes, as well as the effector cells themselves are θ ...Expand abstract
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Cell-mediated immune response in vitro. II. The role of thymus and thymus-derived lymphocytes.
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