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Pregnancy as a natural model of allograft tolerance. Interactions between adherent macrophages and trophoblast populations.

Abstract:

From an immunologic viewpoint, the fetus with its paternal antigens may be considered a successful allograft in the maternal host. Understanding the basis of this host-allograft relationship remains a fundamental unsolved problem in transplantation immunobiology. We have previously demonstrated that local immunoregulation in the murine placenta prevented macrophage activities necessary for an effective response against the intracellular bacterium Listeria monocytogenes. Given the central role...

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Publication status:
Published

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Authors


Redline, RW More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
Journal:
Transplantation
Volume:
48
Issue:
5
Pages:
848-855
Publication date:
1989-11-29
EISSN:
1534-6080
ISSN:
0041-1337
URN:
uuid:829e28c0-1bba-4d65-8067-e47469f014c0
Source identifiers:
483520
Local pid:
pubs:483520

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