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The effect of islet amyloid polypeptide (amylin) and calcitonin gene-related peptide on glucose removal in the anaesthetized rat and on insulin secretion from rat pancreatic islets in vitro.

Abstract:

The effect of intravenous infusion of islet amyloid polypeptide (IAPP/amylin) and calcitonin gene-related peptide (CGRP) on blood glucose and plasma insulin in the basal and glucose-stimulated state was investigated in the anaesthetized rat. Both peptides had no effect on basal blood glucose or plasma insulin but following an intravenous bolus of glucose, CGRP-treated rats were hyperglycaemic and hyperinsulinaemic compared with control animals which were similar to IAPP-treated rats. IAPP had...

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Publication status:
Published

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Publisher copy:
10.1007/bf01117233

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Journal:
Bioscience reports
Volume:
10
Issue:
4
Pages:
339-345
Publication date:
1990-08-05
DOI:
EISSN:
1573-4935
ISSN:
0144-8463
URN:
uuid:822762f0-9719-4927-b563-8d40c3521161
Source identifiers:
72832
Local pid:
pubs:72832

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