Topical capsaicin (high concentration) for chronic neuropathic pain in adults.

Journal article

BACKGROUND: Topical creams with capsaicin are used to treat peripheral neuropathic pain. Following application to the skin capsaicin causes enhanced sensitivity, followed by a period with reduced sensitivity and, after repeated applications, persistent desensitisation. High-concentration (8%) capsaicin patches were developed to increase the amount of capsaicin delivered; rapid delivery was thought to improve tolerability because cutaneous nociceptors are 'defunctionalised' quickly. The singl...

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Authors: Derry, S; Sven-Rice, A; Cole, P; Tan, T; Moore, R

• Publication status: Published
• Journal: Cochrane database of systematic reviews
• Volume: 2
• Issue: 2
• Pages: CD007393
• Publication date: 2013-01-01
• DOI: 10.1002/14651858.cd007393.pub3
• EISSN: 1469-493X
• ISSN: 1469-493X
• Language: English
• Keywords: Administration, Topical; HIV Infections; Diabetic Neuropathies; Adult; Pain, Postoperative; Chronic Disease; Capsaicin; Ointments; Neuralgia; Humans; Neuralgia, Postherpetic; Analgesics; Randomized Controlled Trials as Topic