Journal article
Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi
- Abstract:
-
As part of a drug discovery programme to discover new treatments for human African trypanosomiasis, recombinant trypanothione reductase from Trypanosoma brucei has been expressed, purified and characterized. The crystal structure was solved by molecular replacement to a resolution of 2.3 Å and found to be nearly identical to the T. cruzi enzyme (root mean square deviation 0.6 Å over 482 Cα atoms). Kinetically, the Km for trypanothione disulphide for the T. brucei enzyme was 4.4-fold lower tha...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 817.8KB)
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- Publisher copy:
- 10.1016/j.molbiopara.2009.09.002
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Molecular and Biochemical Parasitology Journal website
- Volume:
- 169
- Issue:
- 1
- Pages:
- 12-19
- Publication date:
- 2010-01-01
- Acceptance date:
- 2009-09-03
- DOI:
- EISSN:
-
1872-9428
- ISSN:
-
0166-6851
- Source identifiers:
-
659853
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:659853
- UUID:
-
uuid:8208d33e-c850-4484-8ef7-3a7487eee600
- Local pid:
- pubs:659853
- Deposit date:
- 2016-12-13
Terms of use
- Copyright holder:
- Elsevier BV
- Copyright date:
- 2010
- Notes:
- © 2009 Elsevier B.V. Open access under CC BY license
- Licence:
- CC Attribution (CC BY)
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