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X-ray structure of human proMMP-1: new insights into procollagenase activation and collagen binding.

Abstract:

Vertebrate collagenases, members of the matrix metalloproteinase (MMP) family, initiate interstitial fibrillar collagen breakdown. It is essential in many biological processes, and unbalanced collagenolysis is associated with diseases such as arthritis, cancer, atherosclerosis, aneurysm, and fibrosis. These metalloproteinases are secreted from the cell as inactive precursors, procollagenases (proMMPs). To gain insights into the structural basis of their activation mechanisms and collagen bind...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m411084200

Authors


Bourenkov, G More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Journal:
The Journal of biological chemistry
Volume:
280
Issue:
10
Pages:
9578-9585
Publication date:
2005-03-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:81edca63-55cc-4dd8-9563-559045089619
Source identifiers:
226913
Local pid:
pubs:226913

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