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Journal article

X-ray structure of human proMMP-1: new insights into procollagenase activation and collagen binding.

Abstract:

Vertebrate collagenases, members of the matrix metalloproteinase (MMP) family, initiate interstitial fibrillar collagen breakdown. It is essential in many biological processes, and unbalanced collagenolysis is associated with diseases such as arthritis, cancer, atherosclerosis, aneurysm, and fibrosis. These metalloproteinases are secreted from the cell as inactive precursors, procollagenases (proMMPs). To gain insights into the structural basis of their activation mechanisms and collagen bind...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m411084200

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
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Journal:
Journal of biological chemistry
Volume:
280
Issue:
10
Pages:
9578-9585
Publication date:
2005-03-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
226913
Language:
English
Keywords:
Pubs id:
pubs:226913
UUID:
uuid:81edca63-55cc-4dd8-9563-559045089619
Local pid:
pubs:226913
Deposit date:
2012-12-19

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