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Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria.

Abstract:

Polygenic autoimmune diseases, such as systemic lupus erythematosus (SLE), are a significant cause of morbidity and mortality worldwide. In recent years, functionally important genetic polymorphisms conferring susceptibility to SLE have been identified, but the evolutionary pressures driving their retention in the gene pool remain elusive. A defunctioning, SLE-associated polymorphism of the inhibitory receptor FcgammaRIIb is found at an increased frequency in African and Asian populations, br...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0608889104

Authors


Clatworthy, MR More by this author
Willcocks, L More by this author
Langhorne, J More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
104
Issue:
17
Pages:
7169-7174
Publication date:
2007-04-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:81dc8526-c278-4a0e-afc5-a96adb24d777
Source identifiers:
40329
Local pid:
pubs:40329

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