Journal article icon

Journal article

The APOE 4 allele modulates brain white matter integrity in healthy adults

Abstract:

The Apolipoprotein E (APOE) ε4 allele is the best-established genetic risk factor for sporadic Alzheimer's disease, and is also associated with structural gray matter and functional brain changes in healthy young, middle-aged and elderly subjects. Because APOE is implicated in brain mechanisms associated with white matter (WM) development and repair, we investigated the potential role played by the APOE polymorphism on WM structure in healthy younger (aged 20-35 years) and older (aged 50-78 y...

Expand abstract

Actions


Access Document


Publisher copy:
10.1038/mp.2010.90

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Filippini, N More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
MacKay, CE More by this author
Journal:
Molecular Psychiatry
Volume:
16
Issue:
9
Pages:
908-916
Publication date:
2011-09-05
DOI:
EISSN:
1476-5578
ISSN:
1359-4184
URN:
uuid:81d86d35-d763-4f55-8f19-81a20491a67c
Source identifiers:
177141
Local pid:
pubs:177141

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP