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Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury.

Abstract:

Once developed, end-stage renal disease cannot be reversed by any current therapy. Bone morphogenetic protein-7 (BMP-7), however, is a possible treatment for reversing end-stage renal disease. Previously, we showed that the BMP antagonist uterine sensitization-associated gene-1 (USAG-1, also known as ectodin and sclerostin domain-containing 1) negatively regulates the renoprotective action of BMP-7. Here, we show that the ratio between USAG-1 and BMP-7 expression increased dramatically in the...

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Publisher copy:
10.1038/sj.ki.5002626

Authors


Economides, AN More by this author
Valenzuela, DM More by this author
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Journal:
Kidney international
Volume:
73
Issue:
2
Pages:
181-191
Publication date:
2008-01-05
DOI:
EISSN:
1523-1755
ISSN:
0085-2538
URN:
uuid:81d01070-6c8e-42a5-880b-740f117c5964
Source identifiers:
245643
Local pid:
pubs:245643

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