Conference icon

Conference

Simulation studies of surrogate endpoint validation using single trial and multitrial statistical approaches.

Abstract:

OBJECTIVE: A schema was recently proposed for assessing the levels of evidence for surrogate validity that included 4 domains: Target, Study Design, Statistical Strength, and Penalties. This report examines one component of the schema. It surveys the literature on methods of statistical validation of surrogate markers and compares these methods head-to-head using simulated datasets. METHODS: Simulated datasets (continuous, multivariate normal) were generated to capture 3 possible relationshi...

Expand abstract
Publication status:
Published

Actions


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Expand authors...
Volume:
34
Issue:
3
Pages:
616-619
Publication date:
2007-03-05
ISSN:
0315-162X
URN:
uuid:81b110c0-2fda-4e87-84fb-563c6c1a089e
Source identifiers:
175390
Local pid:
pubs:175390

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP