Conference item
Simulation studies of surrogate endpoint validation using single trial and multitrial statistical approaches.
- Abstract:
-
OBJECTIVE: A schema was recently proposed for assessing the levels of evidence for surrogate validity that included 4 domains: Target, Study Design, Statistical Strength, and Penalties. This report examines one component of the schema. It surveys the literature on methods of statistical validation of surrogate markers and compares these methods head-to-head using simulated datasets. METHODS: Simulated datasets (continuous, multivariate normal) were generated to capture 3 possible relationshi...
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- Publication status:
- Published
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Bibliographic Details
- Volume:
- 34
- Issue:
- 3
- Pages:
- 616-619
- Host title:
- The Journal of rheumatology
- Publication date:
- 2007-03-01
- Event location:
- Canada
- ISSN:
-
0315-162X
- Source identifiers:
-
175390
Item Description
- Keywords:
- Pubs id:
-
pubs:175390
- UUID:
-
uuid:81b110c0-2fda-4e87-84fb-563c6c1a089e
- Local pid:
- pubs:175390
- Deposit date:
- 2013-11-16
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- Copyright date:
- 2007
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