Identification of common variants associated with human hippocampal and intracranial volumes.

Stein, J; Medland, SE; Vasquez, A; Hibar, D; Senstad, R; Winkler, A; Toro, R; Appel, K; Bartecek, R; Bergmann, Ø; Bernard, M; Brown, A; Cannon, D; Chakravarty, M; Christoforou, A; Domin, M; Grimm, O; Hollinshead, M; Holmes, A; Homuth, G; Hottenga, J; Langan, C; Lopez, L; Hansell, N; Hwang, K; Kim, S; Laje, G; Lee, P; Liu, X; Loth, E; Lourdusamy, A; Mattingsdal, M; Mohnke, S; Maniega, S; Nho, K; Nugent, A; O'Brien, C; Papmeyer, M; Pütz, B; Ramasamy, A; Rasmussen, J; Rijpkema, M; Risacher, S; Roddey, J; Rose, E; Ryten, M; Shen, L; Sprooten, E; Strengman, E; Teumer, A; Trabzuni, D; Turner, J; van Eijk, K; van Erp, T; van Tol, M; Wittfeld, K; Wolf, C; Woudstra, S; Aleman, A; Alhusaini, S; Almasy, L; Binder, E; Brohawn, D; Cantor, R; Carless, M; Corvin, A; Czisch, M; Curran, J; Davies, G; Almeida, d; Delanty, N; Depondt, C; Duggirala, R; Dyer, T; Erk, S; Fagerness, J; Fox, P; Freimer, N; Gill, M; Göring, H; Hagler, D; Hoehn, D; Holsboer, F; Hoogman, M; Hosten, N; Jahanshad, N; Johnson, M; Kasperaviciute, D; Kent, J; Kochunov, P; Lancaster, J; Lawrie, S; Liewald, D; Mandl, R; Matarin, M; Mattheisen, M; Meisenzahl, E; Melle, I; Moses, E; Mühleisen, T; Nauck, M; Nöthen, M; Olvera, R; Pandolfo, M; Pike, G; Puls, R; Reinvang, I; Rentería, M; Rietschel, M; Roffman, J; Royle, N; Rujescu, D; Savitz, J; Schnack, H; Schnell, K; Seiferth, N; Smith, C; Steen, V; Hernández, V; Van den Heuvel, M; van der Wee, N; Van Haren, N; Veltman, J; Völzke, H; Walker, R; Westlye, LT; Whelan, C; Agartz, I; Boomsma, D; Cavalleri, G; Dale, A; Djurovic, S; Drevets, W; Hagoort, P; Hall, J; Heinz, A; Jack, C; Foroud, T; Le Hellard, S; Macciardi, F; Montgomery, G; Poline, J; Porteous, D; Sisodiya, S; Starr, J; Sussmann, J; Toga, A; Veltman, D; Walter, H; Weiner, M; Bis, J; Ikram, M; Smith, A; Gudnason, V; Tzourio, C; Vernooij, M; Launer, L; DeCarli, C; Seshadri, S; Andreassen, O; Apostolova, L; Bastin, M; Blangero, J; Brunner, H; Buckner, R; Cichon, S; Coppola, G; de Zubicaray, G; Deary, I; Donohoe, G; de Geus, E; Espeseth, T; Fernández, G; Glahn, D; Grabe, H; Hardy, J; Hulshoff Pol, H; Jenkinson, M; Kahn, R; McDonald, C; McIntosh, A; McMahon, F; McMahon, K; Meyer-Lindenberg, A; Morris, D; Müller-Myhsok, B; Nichols, T; Ophoff, R; Paus, T; Pausova, Z; Penninx, B; Potkin, S; Sämann, P; Saykin, A; Schumann, G; Smoller, J; Wardlaw, J; Weale, M; Martin, N; Franke, B; Wright, M; Thompson, P

Journal article

Identification of common variants associated with human hippocampal and intracranial volumes.

Abstract:: Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer's disease and is reduced in schizophrenia, major depression and mesial temporal lobe epilepsy. Whereas many brain imaging phenotypes are highly heritable, identifying and replicating genetic influences has been difficult, as small effects and the high costs of magnetic resonance imaging (MRI) have led to underpowered studies. Here we report genome-wide association meta-analyses and replication for mean bilateral hippocampal, total brain and intracranial volumes from a large multinational consortium. The intergenic variant rs7294919 was associated with hippocampal volume (12q24.22; N = 21,151; P = 6.70 × 10⁻¹⁶) and the expression levels of the positional candidate gene TESC in brain tissue. Additionally, rs10784502, located within HMGA2, was associated with intracranial volume (12q14.3; N = 15,782; P = 1.12 × 10⁻¹²). We also identified a suggestive association with total brain volume at rs10494373 within DDR2 (1q23.3; N = 6,500; P = 5.81 × 10⁻⁷).

Publication status:: Published

Peer review status:: Peer reviewed

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Cite

Cite this record

APA Style

Stein, J., Medland, S. E., Vasquez, A., Hibar, D., Senstad, R., Winkler, A., Toro, R., Appel, K., Bartecek, R., Bergmann, Ø., Bernard, M., Brown, A., Cannon, D., Chakravarty, M., Christoforou, A., Domin, M., Grimm, O., Hollinshead, M., Holmes, A., … Thompson, P. (2012). Identification of common variants associated with human hippocampal and intracranial volumes. Nature Genetics, 44(5), 552–561.

MLA Style

Stein, J., et al. “Identification of Common Variants Associated with Human Hippocampal and Intracranial Volumes.” Nature Genetics, vol. 44, no. 5, Nature Publishing Group, 2012, pp. 552–61.

Chicago Style

Stein, J, SE Medland, A Vasquez, D Hibar, R Senstad, A Winkler, R Toro, et al. 2012. “Identification of Common Variants Associated with Human Hippocampal and Intracranial Volumes.” Nature Genetics 44 (5): 552–61.
Share
Print