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Identification of common variants associated with human hippocampal and intracranial volumes.

Abstract:

Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer's disease and is reduced in schizophrenia, major depression and mesial temporal lobe epilepsy. Whereas many brain imaging phenotypes are highly heritable, identifying and replicating genetic influences has been difficult, as small effects and the high costs of magnetic resonan...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ng.2250

Authors


Medland, SE More by this author
Vasquez, AA More by this author
Senstad, RE More by this author
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Genetics Journal website
Volume:
44
Issue:
5
Pages:
552–561
Publication date:
2012-05-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:819cba79-4870-47e9-85cd-64ae5dfc68a3
Source identifiers:
325674
Local pid:
pubs:325674

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