Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials.

Journal article

BACKGROUND: Long-term follow-up of randomised trials of aspirin in prevention of vascular events showed that daily aspirin reduced the incidence of colorectal cancer and several other cancers and reduced metastasis. However, statistical power was inadequate to establish effects on less common cancers and on cancers in women. Observational studies could provide this information if results can be shown to be reliable. We therefore compared effects of aspirin on risk and outcome of cancer in obs...

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Authors: Algra, A; Rothwell, P

• Publication status: Published
• Journal: Lancet. Oncology
• Volume: 13
• Issue: 5
• Pages: 518-527
• Publication date: 2012-05-01
• DOI: 10.1016/S1470-2045(12)70112-2
• EISSN: 1474-5488
• ISSN: 1470-2045
• Language: English
• Keywords: Antineoplastic Agents; Neoplasm Metastasis; Randomized Controlled Trials as Topic; Risk Factors; Neoplasms; Case-Control Studies; Humans; Incidence; Cohort Studies; Aspirin