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A solution to the 2-pyridyl organometallic cross-coupling problem: regioselective catalytic direct arylation of pyridine N-oxides.

Abstract:
Direct arylation reactions of pyridine N-oxides occur in excellent yield with complete selectivity for the 2-position with a wide range of aryl bromides. This reactivity permits the use of inexpensive, commercially available, and bench-stable pyridine N-oxides as replacements for problematic 2-metallapyridines in palladium-catalyzed cross-coupling reactions.
Publication status:
Published

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Publisher copy:
10.1021/ja056800x

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Journal:
Journal of the American Chemical Society More from this journal
Volume:
127
Issue:
51
Pages:
18020-18021
Publication date:
2005-12-01
DOI:
EISSN:
1520-5126
ISSN:
0002-7863


Language:
English
Pubs id:
pubs:416031
UUID:
uuid:811e188a-1b13-4889-9e59-21c6a5eba322
Local pid:
pubs:416031
Source identifiers:
416031
Deposit date:
2013-11-16
ARK identifier:

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