Class 1 major histocompatibility complex antigens on human extra-villous trophoblast.

Journal article

Using immunohistological techniques, class 1 products of the major histocompatibility complex (MHC) have been demonstrated on various forms of human extra-villous trophoblast in placental tissues taken from first, second and third trimester pregnancies. This contrasts with the absence of class 1 MHC antigens on all forms of villous trophoblast. The extra-villous trophoblast which reacted with antibodies to monomorphic class 1 MHC antigens consistently failed to bind HLA-A or HLA-B antibodies specific for the foetal phenotype. This suggests, but does not prove, that the MHC antigen expression of trophoblast may be restricted to HLA-C or some other undefined class 1 antigen.

Authors: Redman, C; Mcmichael, A; Stirrat, G; Sunderland, C; Ting, A

• Publication status: Published
• Journal: Immunology
• Volume: 52
• Issue: 3
• Pages: 457-468
• Publication date: 1984-07-01
• EISSN: 1365-2567
• ISSN: 0019-2805
• Language: English
• Keywords: HLA-B Antigens; Placenta; Antibody Specificity; Pregnancy; Chorion; beta 2-Microglobulin; Female; HLA-A Antigens; Trophoblasts; Humans; Immunoenzyme Techniques; Major Histocompatibility Complex; HLA-C Antigens; HLA Antigens; Epitopes