The La-related proteins, a family with connections to cancer

Journal article

Abstract:: The evolutionarily-conserved La-related protein (LARP) family currently comprises Genuine La, LARP1, LARP1b, LARP4, LARP4b, LARP6 and LARP7. Emerging evidence suggests each LARP has a distinct role in transcription and/or mRNA translation that is attributable to subtle sequence variations within their La modules and specific C-terminal domains. As emerging research uncovers the function of each LARP, it is evident that La, LARP1, LARP6, LARP7 and possibly LARP4a and 4b are dysregulated in cancer. Of these, LARP1 is the first to be demonstrated to drive oncogenesis. Here, we review the role of each LARP and the evidence linking it to malignancy. We discuss a future strategy of targeting members of this protein family as cancer therapy.

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Keywords:: proliferation

LARP1

translation

SS-B

mRNA

cancer

RNA-binding

transcription

RBP

LARP
Pubs id:: pubs:571172
UUID:: uuid:80fef12b-f77a-4ea0-ad63-5f3f7faad94f
Local pid:: pubs:571172
Source identifiers:: 571172
Deposit date:: 2015-10-21

Copyright holder:: Stavraka and Blagden
Notes:: Copyright © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article
distributed under the terms and conditions of the Creative Commons Attribution license
(http://creativecommons.org/licenses/by/4.0/).

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