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Pharmacokinetics and pharmacodynamics of dichloroacetate in children with lactic acidosis due to severe malaria.

Abstract:

Lactic acidosis frequently complicates severe malaria in African children, and is a strong independent predictor of mortality. We tested the hypothesis that sodium dichloroacetate (DCA), an activator of pyruvate dehydrogenase, rapidly reduces hyperlactataemia in this patient population. Eighteen children with severe malaria and capillary plasma lactate > or = 5 mM were randomized to receive either intramuscular quinine plus a single 50 mg/kg intravenous infusion of DCA in saline, or quinin...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Role:
Author
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Journal:
QJM : monthly journal of the Association of Physicians
Volume:
88
Issue:
5
Pages:
341-349
Publication date:
1995-05-05
EISSN:
1460-2393
ISSN:
1460-2725
URN:
uuid:80b790f4-c1fa-4e89-9a9c-4754416ac159
Source identifiers:
44887
Local pid:
pubs:44887

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