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Plate tectonics of virus shell assembly and reorganization in phage φ8, a distant relative of mammalian reoviruses.

Abstract:

The hallmark of a virus is its capsid, which harbors the viral genome and is formed from protein subunits, which assemble following precise geometric rules. dsRNA viruses use an unusual protein multiplicity (120 copies) to form their closed capsids. We have determined the atomic structure of the capsid protein (P1) from the dsRNA cystovirus Φ8. In the crystal P1 forms pentamers, very similar in shape to facets of empty procapsids, suggesting an unexpected assembly pathway that proceeds via a ...

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Publication status:
Published

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Publisher copy:
10.1016/j.str.2013.06.017

Authors


El Omari, K More by this author
Ravantti, JJ More by this author
Walter, TS More by this author
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Journal:
Structure (London, England : 1993)
Volume:
21
Issue:
8
Pages:
1384-1395
Publication date:
2013-08-05
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
URN:
uuid:80a10001-c367-48e2-8225-9b541f4d7e88
Source identifiers:
415378
Local pid:
pubs:415378

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