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High-dose vs standard-dose influenza vaccine in older adults with diabetes: a secondary analysis of the DANFLU-2 Randomized Clinical Trial

Abstract:

Importance: Influenza infection poses a substantial risk of severe complications, particularly in older adults and high-risk populations, such as individuals with diabetes. The high-dose inactivated influenza vaccine (HD-IIV) has demonstrated superior efficacy against influenza infection compared with the standard-dose inactivated influenza vaccine (SD-IIV) among adults 65 years or older. However, there is limited evidence on its effectiveness in preventing severe respirat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1001/jamainternmed.2025.7286

Authors


Publisher:
American Medical Association
Journal:
JAMA Internal Medicine More from this journal
Publication date:
2026-01-12
Acceptance date:
2025-11-12
DOI:
EISSN:
2168-6114
ISSN:
2168-6106


Language:
English
Keywords:
Pubs id:
2330100
Local pid:
pubs:2330100
Deposit date:
2025-11-20
ARK identifier:

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