The positive perspective paradigm: proposal of a model to mitigate the impact of chronic inflammatory arthritis through comprehensive and early intervention

Journal article

Many people with chronic inflammatory arthritis (IA) experience significant disease impact, even with well-controlled disease activity. For rheumatoid arthritis (RA), 20-50% of patients in remission still report pain, disability, fatigue or negative illness perceptions, leading to poorer long-term outcomes. However, evidence shows that long-term patient-reported outcomes improve when remission is achieved early, and that this is at least partly explained by a positive influence on psychological factors like illness perceptions. Based on these insights and a narrative literature review, we propose a conceptual framework to support clinical practice and further research in the prevention of long-term impact of chronic IA, using the example of RA. Building on Leventhal’s Model of Self-Regulation, the “positive perspective paradigm” postulates that the early stages of a chronic inflammatory disease present an optimal time window where appropriate intervention might positively influence one’s health perspective, in turn contributing to reduced long-term disease impact. Through the model, we discuss how pharmacological control of inflammation can be integrated with patient education and psychosocial support, emphasising early intervention and positive communication whenever possible. We hypothesise that these interventions have both direct effects on the long-term impact of chronic IA and indirect effects through a positive influence on the patient’s health perspective. Fostering a positive perspective is thus the focal point of the model. By proposing this paradigm, we aim to provide a foundation for further validation in independent cohorts or other chronic inflammatory conditions, with the ultimate goal of implementing it to reduce long-term disease impact and promote wellbeing.

Authors: Doumen, M; Gossec, L; Ndosi, M; Taylor, PC; Thelissen, M

• Publication status: In press
• Peer review status: Peer reviewed
• Publisher: Elsevier
• Journal: Annals of the Rheumatic Diseases
• Publication date: 2026-02-05
• Acceptance date: 2026-01-02
• DOI: 10.1016/j.ard.2026.01.001
• EISSN: 1468-2060
• ISSN: 0003-4967
• Language: English
• Keywords: rheumatoid arthritis; patient-reported outcomes; quality of life; illness perceptions; patient education; treatment strategies