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A discrete domain of the human TrkB receptor defines the binding sites for BDNF and NT-4.

Abstract:

TrkB is a member of the Trk family of tyrosine kinase receptors. In vivo, the extracellular region of TrkB is known to bind, with high affinity, the neurotrophin protein brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4). We describe the expression and purification of the second Ig-like domain of human TrkB (TrkBIg(2)) and show, using surface plasmon resonance, that this domain is sufficient to bind BDNF and NT-4 with subnanomolar affinity. BDNF and NT-4 may have therapeutic i...

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Publication status:
Published

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Publisher copy:
10.1006/bbrc.2002.6468

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Journal:
Biochemical and biophysical research communications
Volume:
291
Issue:
3
Pages:
501-507
Publication date:
2002-03-05
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
URN:
uuid:8071e6e6-a4f4-46e9-bd63-59e6c6ec096b
Source identifiers:
32055
Local pid:
pubs:32055

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