Journal article
Plasma cell antibody repertoire analysis following administration of meningococcal polysaccharide and protein-polysaccharide conjugate vaccines: evidence of distinct patterns of B cell activation
- Abstract:
- Vaccines against N.meningitidis have been developed from the plain capsular polysaccharide, (T-independent antigen), and by covalently linking the polysaccharide to a protein carrier to from a polysaccharide-protein conjugate (T-dependent antigen). To investigate differences in the immune response to these two vaccine types, plasma cells were isolated 7 days following administration of meningococcal serogroup ACWY polysaccharide and conjugate vaccines. Additionally, naïve, marginal zone, IgM memory and IgG memory B cell subsets were isolated at baseline. Next-generation sequencing was used to obtain B cell receptor sequence data from all populations.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 51.7KB, Terms of use)
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- Publisher copy:
- 10.1111/imm.12406
Authors
- Publisher:
- Wiley
- Journal:
- Immunology More from this journal
- Volume:
- 143
- Pages:
- 62-62
- Publication date:
- 2014-11-28
- DOI:
- EISSN:
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1365-2567
- ISSN:
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0019-2805
- Pubs id:
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pubs:502120
- UUID:
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uuid:8071a218-fcf4-4eee-8b0b-1e37c40d1a4e
- Local pid:
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pubs:502120
- Source identifiers:
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502120
- Deposit date:
-
2015-01-09
- ARK identifier:
Terms of use
- Copyright holder:
- Wiley
- Copyright date:
- 2014
- Notes:
- © 2014 John Wiley and Sons Ltd. This is the accepted manuscript version of the article. The final version is available online from Wiley at: [10.1111/imm.12406]
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