Journal article
A model informed approach to assess the risk of checkpoint inhibitors induced myocarditis
- Abstract:
- Immune checkpoint inhibitors (ICIs), as a novel immunotherapy, are designed to modulate the immune system to attack malignancies. Despite their promising benefits, immune-related adverse events (IRAEs) may occur, and incidences are bound to increase with surging demand of this class of drugs in treating cancer. Myocarditis, although rare compared to other IRAEs, has a significantly higher fatal frequency. Due to the overwhelming complexity of the immune system, this condition is not well understood, despite the significant research efforts devoted to it. To better understand the development and progression of autoimmune myocarditis and the roles of ICIs therein, we suggest a new approach: mathematical modelling. Mathematical modelling of myocarditis has enormous potential to determine which parts of the immune system are critical to the development and progression of the disease, and therefore warrant further investigation. We provide the immunological background needed to develop a mathematical model of this disease and review relevant existing models of immunology that serve as the mathematical inspiration needed to develop this field.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.3MB, Terms of use)
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- Publisher copy:
- 10.3389/fphar.2022.966180
Authors
- Publisher:
- Frontiers Media
- Journal:
- Frontiers in Pharmacology More from this journal
- Volume:
- 13
- Article number:
- 966180
- Publication date:
- 2022-09-26
- Acceptance date:
- 2022-08-23
- DOI:
- EISSN:
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1663-9812
- Language:
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English
- Keywords:
- Pubs id:
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1278376
- Local pid:
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pubs:1278376
- Deposit date:
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2022-09-11
Terms of use
- Copyright holder:
- Van der Vegt et al.
- Copyright date:
- 2022
- Rights statement:
- Copyright © 2022 van der Vegt, Wang, Polonchuk, Wang, Waters and Baker. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Licence:
- CC Attribution (CC BY)
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