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Recent advances in modelling of cerebellar ataxia using induced pluripotent stem cells

Abstract:

The cerebellar ataxias are a group of incurable brain disorders that are caused primarily by the progressive dysfunction and degeneration of cerebellar Purkinje cells. The lack of reliable disease models for the heterogeneous ataxias has hindered the understanding of the underlying pathogenic mechanisms as well as the development of effective therapies for these devastating diseases. Recent advances in the field of induced pluripotent stem cell (iPSC) technology offer new possibilities to bet...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Department:
Wadham College
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Rosetrees Trust More from this funder
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Publisher:
SciAccess Publishers Publisher's website
Journal:
Journal of Neurology and Neuromedicine Journal website
Volume:
2
Issue:
7
Pages:
11-15
Publication date:
2017-07-28
Acceptance date:
2017-07-10
Pubs id:
pubs:710039
URN:
uri:80615bc7-eebc-452e-830e-2412e5bd4c63
UUID:
uuid:80615bc7-eebc-452e-830e-2412e5bd4c63
Local pid:
pubs:710039

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