Selection of the T cell repertoire.

Journal article

Advances in gene technology have allowed the manipulation of molecular interactions that shape the T cell repertoire. Although recognized as fundamental aspects of T lymphocyte development, only recently have the mechanisms governing positive and negative selection been examined at a molecular level. Positive selection refers to the active process of rescuing MHC-restricted thymocytes from programmed cell death. Negative selection refers to the deletion or inactivation of potentially autoreactive thymocytes. This review focuses on interactions during thymocyte maturation that define the T cell repertoire, with an emphasis placed on current literature within this field.

Authors: Sebzda, E; Mariathasan, S; Ohteki, T; Jones, R; Bachmann, M

• Publication status: Published
• Journal: Annual review of immunology
• Volume: 17
• Issue: 1
• Pages: 829-874
• Publication date: 1999-01-01
• DOI: 10.1146/annurev.immunol.17.1.829
• EISSN: 1545-3278
• ISSN: 0732-0582
• Language: English
• Keywords: T-Lymphocytes; Animals; Cell Survival; Transcription Factors; Receptors, Antigen, T-Cell; Major Histocompatibility Complex; Peptides; Models, Biological; Humans; Receptors, Tumor Necrosis Factor; Calcium-Calmodulin-Dependent Protein Kinases; Autoimmune Diseases; Isoenzymes; Type C Phospholipases; Phospholipase C gamma; Cell Differentiation; Apoptosis