Placental Protein 13 and Syncytiotrophoblast Basement Membrane Ultrastructures in Preeclampsia

Journal article

Background and Objectives: Preeclampsia has been linked to an inflammatory response that may be brought on by endothelial cell dysfunction. This paper investigates the pathomechanism of syncytiotrophoblast basement membrane (STBM) damage and Placental Protein 13 (PP13) release, which may have a role in systemic endothelial dysfunction in preeclampsia. Materials and Methods: This comparative cross-sectional study involves 54 preeclampsia patients (27 early-onset preeclampsia and 27 late-onset preeclampsia) and 27 pregnant women with normal blood pressure. An enzyme-linked immunosorbent assay was performed to evaluate maternal blood levels of PP13. Following birth, a portion of the placenta was collected for transmission electron microscope (TEM) and immunohistochemical (IHC) analysis. The data were analyzed using STATA version 15. Results: PP13 expression in the placental syncytiotrophoblast was significantly lower in the early-onset preeclampsia, compared to late-onset preeclampsia and normotensive pregnancy, group (p Conclusions: PP13 and STBM damage may play a role in systemic endothelial dysfunction in preeclampsia.

Authors: Lestari, PM; Wibowo, N; Prasmusinto, D; Yamin, M; Siregar, NC

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: MDPI
• Journal: Medicina
• Volume: 60
• Issue: 7
• Pages: 1077
• Publication date: 2024-06-30
• DOI: 10.3390/medicina60071077
• EISSN: 1648-9144
• ISSN: 1010-660X
• Pmid: 39064506
• Language: English
• Keywords: Female; Placental Protein 13; Trophoblasts; Adult; Syncytiotrophoblast Basement Membrane; endothelial dysfunction; Enzyme-Linked Immunosorbent Assay; Galectins; Pregnancy Proteins; Basement Membrane; Cross-Sectional Studies; Pregnancy; Placenta; Microscopy, Electron, Transmission; Preeclampsia; Immunohistochemistry; Pre-Eclampsia; Humans