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Extracellularly applied ruthenium red and cADP ribose elevate cytosolic Ca2+ in isolated rat osteoclasts.

Abstract:

We demonstrated recently that the divalent cation-sensing receptor on the osteoclast, the Ca2+ receptor (CaR), is a functional component of a cell surface-expressed ryanodine receptor-like molecule (RyR). The objective of the present study was to further characterize this putative RyR by use of the two well-known cell-impermeant RyR modulators, ruthenium red and adenosine 3',5'-cyclic diphosphate ribose (cADPr). We found that, when applied extracellularly, ruthenium red (5 x 10(-8)-10(-4) M) ...

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Authors


Adebanjo, OA More by this author
Shankar, VS More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Journal:
The American journal of physiology
Volume:
270
Issue:
3 Pt 2
Pages:
F469-F475
Publication date:
1996-03-05
ISSN:
0002-9513
URN:
uuid:801f7e89-204e-4ca1-ae59-888ab6b3e3d5
Source identifiers:
475716
Local pid:
pubs:475716

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