Journal article
Changing metabolism in differentiating cardiac progenitor cells - can stem cells become metabolically flexible cardiomyocytes?
- Abstract:
- The heart is a metabolic omnivore and the adult heart selects the substrate best suited for each circumstance, with fatty acid oxidation preferred in order to fulfill the high energy demand of the contracting myocardium. The fetal heart exists in an hypoxic environment and obtains the bulk of its energy via glycolysis. After birth, the “fetal switch” to oxidative metabolism of glucose and fatty acids has been linked to the loss of the regenerative phenotype. Various stem cell types have been used in differentiation studies, but most are cultured in high glucose media. This does not change in the majority of cardiac differentiation protocols. Despite the fact that metabolic state affects marker expression and cellular function and activity, the substrate composition is currently being overlooked. In this review we discuss changes in cardiac metabolism during development, the various protocols used to differentiate progenitor cells to cardiomyocytes, what is known about stem cell metabolism and how consideration of metabolism can contribute toward maturation of stem cell-derived cardiomyocytes.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.6MB, Terms of use)
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- Publisher copy:
- 10.3389/fcvm.2018.00119
Authors
- Publisher:
- Frontiers Media
- Journal:
- Frontiers in Cardiovascular Medicine More from this journal
- Volume:
- 5
- Pages:
- 119
- Publication date:
- 2018-09-19
- Acceptance date:
- 2018-08-10
- DOI:
- EISSN:
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2297-055X
- Keywords:
- Pubs id:
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pubs:904464
- UUID:
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uuid:801f1a3a-8fc5-4fa5-b464-a1c0ac42e99e
- Local pid:
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pubs:904464
- Source identifiers:
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904464
- Deposit date:
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2018-08-10
Terms of use
- Copyright holder:
- Malandraki-Miller et al
- Copyright date:
- 2018
- Notes:
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© 2018 Malandraki-Miller, Lopez, Al-Siddiqi and Carr. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction
in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Licence:
- CC Attribution (CC BY)
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