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Synthesis of (-)-(Z)-deoxypukalide.

Abstract:
(Chemical Equation Presented) Closing the deal: A ring-closing metathesis (RCM)/aromatization protocol, followed by a regioselective Negishi cross-coupling reaction and macrolactonization, with subsequent RCM mediate the synthesis of (-)-(Z)-deoxypukalide in 12 linear steps and 15% overall yield (see retrosynthesis; TBS=tert-butyldimethylsilyl, TIPS=triisopropylsilyl). © 2008 Wiley-VCH Verlag GmbH and Co. KGaA.
Publication status:
Published

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Publisher copy:
10.1002/anie.200802703

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author


Journal:
Angewandte Chemie (International ed. in English) More from this journal
Volume:
47
Issue:
38
Pages:
7314-7316
Publication date:
2008-01-01
DOI:
EISSN:
1521-3773
ISSN:
1433-7851


Language:
English
Keywords:
Pubs id:
pubs:34346
UUID:
uuid:8001c0eb-9ea8-4108-a42a-0fa410eaf70c
Local pid:
pubs:34346
Source identifiers:
34346
Deposit date:
2012-12-19

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