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The val158met COMT polymorphism's effect on atrophy in healthy aging and Parkinson's disease.

Abstract:

We investigated whether the val(158)met functional polymorphism of catechol-o-methyltransferase influenced age-related changes in grey matter density and volume, both in healthy individuals (n=80, ages 18-79) and those with Parkinson's disease (n=50). Global grey matter volumes and voxelwise estimates of grey matter volume and density were determined from structural magnetic resonance images at 3T. Male and female ValVal homozygotes (low prefrontal cortical dopamine) had more grey matter in e...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
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Journal:
Neurobiology of aging
Volume:
31
Issue:
6
Pages:
1064-1068
Publication date:
2010-06-05
DOI:
EISSN:
1558-1497
ISSN:
0197-4580
URN:
uuid:7ff4b82a-38e7-4753-9927-66564563a22d
Source identifiers:
383298
Local pid:
pubs:383298

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