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The val158met COMT polymorphism's effect on atrophy in healthy aging and Parkinson's disease.

Abstract:

We investigated whether the val(158)met functional polymorphism of catechol-o-methyltransferase influenced age-related changes in grey matter density and volume, both in healthy individuals (n=80, ages 18-79) and those with Parkinson's disease (n=50). Global grey matter volumes and voxelwise estimates of grey matter volume and density were determined from structural magnetic resonance images at 3T. Male and female ValVal homozygotes (low prefrontal cortical dopamine) had more grey matter in e...

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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Journal:
Neurobiology of aging
Volume:
31
Issue:
6
Pages:
1064-1068
Publication date:
2010-06-01
DOI:
EISSN:
1558-1497
ISSN:
0197-4580
Source identifiers:
383298
Language:
English
Keywords:
Pubs id:
pubs:383298
UUID:
uuid:7ff4b82a-38e7-4753-9927-66564563a22d
Local pid:
pubs:383298
Deposit date:
2013-11-16

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