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Global emergence and population dynamics of divergent serotype 3 CC180 pneumococci

Abstract:

Streptococcus pneumoniae serotype 3 remains a significant cause of morbidity and mortality worldwide, despite inclusion in the 13-valent pneumococcal conjugate vaccine (PCV13). Serotype 3 increased in carriage since the implementation of PCV13 in the USA, while invasive disease rates remain unchanged. We investigated the persistence of serotype 3 in carriage and disease, through genomic analyses of a global sample of 301 serotype 3 isolates of the Netherlands3–31 (PMEN31) clone CC180, combine...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.1007438

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ORCID:
0000-0002-8611-5241
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ORCID:
0000-0001-6848-0846
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ORCID:
0000-0002-4553-7894
Thompson, CM More by this author
Ghouila, A More by this author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Pathogens Journal website
Volume:
14
Issue:
11
Pages:
Article: e1007438
Publication date:
2018-11-26
Acceptance date:
2018-10-25
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Pubs id:
pubs:946688
URN:
uri:7f73d5f6-a38a-4285-95cc-5de709ced5ba
UUID:
uuid:7f73d5f6-a38a-4285-95cc-5de709ced5ba
Local pid:
pubs:946688
Language:
English

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