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Sonothrombolysis with magnetically targeted microbubbles

Abstract:

Microbubble-enhanced sonothrombolysis is a promising approach to increase the safety and efficacy of current pharmacological treatments for ischemic stroke. Maintaining therapeutic concentrations of microbubbles and drugs at the clot site however poses a challenge. The objective of this study was to investigate the efficacy of magnetic microbubble targeting upon clot lysis rates in vitro. Retracted whole porcine blood clots were placed in a flow phantom of a partially occluded middle cerebral...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Subgroup:
Institute of Biomedical Engineering
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Subgroup:
Institute of Biomedical Engineering
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Subgroup:
Institute of Biomedical Engineering
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Subgroup:
Institute of Biomedical Engineering
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Subgroup:
Institute of Biomedical Engineering
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Publisher:
Elsevier Publisher's website
Journal:
Ultrasound in Medicine and Biology Journal website
Volume:
45
Issue:
5
Pages:
1151-1163
Publication date:
2019-02-14
Acceptance date:
2018-12-22
DOI:
EISSN:
1879-291X
ISSN:
0301-5629
Pubs id:
pubs:969851
URN:
uri:7f4c4c1a-f648-4761-8b2e-0761331c031f
UUID:
uuid:7f4c4c1a-f648-4761-8b2e-0761331c031f
Local pid:
pubs:969851

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