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Journal article

Prevention of the dystrophic phenotype in dystrophin/utrophin-deficient muscle following adenovirus-mediated transfer of a utrophin minigene.

Abstract:

Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder caused by the lack of a subsarcolemmal protein, dystrophin. We have previously shown that the dystrophin-related protein, utrophin is able to compensate for the lack of dystrophin in the mdx mouse, the mouse model for DMD. Here, we explore whether utrophin delivered to the limb muscle of dystrophin/utrophin-deficient double knockout (dko) neonatal mice can protect the muscle from subsequent dystrophic damage. Utrophin ...

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Publication status:
Published

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Publisher copy:
10.1038/sj.gt.3301066

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Journal:
Gene therapy
Volume:
7
Issue:
3
Pages:
201-204
Publication date:
2000-02-05
DOI:
EISSN:
1476-5462
ISSN:
0969-7128
URN:
uuid:7f396ba3-65d5-45c4-b8db-0c4708d66d48
Source identifiers:
106247
Local pid:
pubs:106247

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