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Depletion of CD25+ regulatory cells results in suppression of melanomagrowth and induction of autoreactivity in mice

Abstract:

Treatment with monoclonal antibodies (mAbs) specific for CD25 (anti-CD25 mAb) has been shown to suppress growth of a variety of different tumours in mice. These studies did not however determine whether or not anti-CD25 mAbs facilitate tumour rejection by depletion of regulatory T cells or by binding to tumour-specific effector cells. Using a murine model of melanoma we have found that treatment of mice with anti-CD25 mAb facilitates long-term CD4+ T cell-mediated tumour immunity through depl...

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Authors


Dahm-Vicker, M More by this author
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Journal:
Cancer Immunity
Volume:
5
Pages:
1-12
Publication date:
2002-02-22
ISSN:
1424-9634
URN:
uuid:7ed65378-f193-42b2-a46a-2f94369eff0b
Source identifiers:
95142
Local pid:
pubs:95142
Language:
English
Keywords:

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