Brucella melitensis 16M is a Gram-negative alpha2-proteobacterium responsible for abortion in goats and for Malta fever in humans. This facultative intracellular pathogen invades into and survives within both professional and non-professional phagocytes. Signature-tagged mutagenesis (STM) was used to identify genes required for the in vivo pathogenesis of Brucella. A library of transposon mutants was screened in a murine infection model. Out of 672 mutants screened, 20 were not recovered afte...Expand abstract
- Publisher copy:
- Copyright date:
Identification and characterization of in vivo attenuated mutants of Brucella melitensis.
If you are the owner of this record, you can report an update to it here: Report update to this record