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Roles of pre-treatment time and junctional proteins in Caco-2 cell microparticle uptake

Abstract:

Microparticle uptake in the small intestine is relevant to both the delivery of pharmaceutics and exposure to environmental pollutants. The Caco-2 enterocyte model is a useful tool to study the parameters that affect epithelial microparticle permeability and the mechanisms controlling them. The current study used this model to explore further the different effects of 10% ethanol v/v or ice on transepithelial resistance (TER), microparticle uptake and immunofluorescent labelling of intercellul...

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
International Journal of Pharmaceutics
Volume:
407
Issue:
1-2
Pages:
21-30
Publication date:
2011-04-04
DOI:
ISSN:
0378-5173
URN:
uuid:7ebddac1-6c38-4016-8a19-65e90c9a018f
Source identifiers:
127405
Local pid:
pubs:127405

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