Journal article
Heterogeneous relationships of squamous and basal cell carcinomas of the skin with smoking: the UK Million Women Study and meta-analysis of prospective studies
- Abstract:
-
Introduction
Published findings on the associations between smoking and the incidence of cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are inconsistent. We aimed to generate prospective evidence on these relationships, overall and by anatomical site.
Methods
We followed 1,223,626 women without prior cancer by electronic linkage to national cancer registration data. Questionnaire information about smoking and other factors was recorded at recruitment (1996-2001) and every 3-5 years subsequently. Cox regression yielded adjusted relative risks (RRs) comparing smokers versus never-smokers.
Results
After 14 (SD4) years follow-up per woman, 6699 had a first registered cutaneous SCC and 48,666 a first BCC. In current versus never-smokers, SCC incidence was increased (RR=1.22, 95%CI 1.15-1.31) but BCC incidence was decreased (RR=0.80, 0.78-0.82). RRs varied substantially by anatomical site; for the limbs, current smoking was associated with an increased incidence of SCC (1.55, 1.41-1.71) and a decreased incidence of BCC (0.72, 0.66-0.79), but for facial lesions there was little association of current smoking with either SCC (0.93, 0.82-1.06) or BCC (0.92, 0.88-0.96). Findings in meta-analyses of results from this and 7 other prospective studies were largely dominated by the findings in this study.
Conclusion
Smoking-associated risks for cutaneous SCC and BCC are opposite to each other, and may vary by anatomical site.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 433.5KB, Terms of use)
-
- Publisher copy:
- 10.1038/s41416-018-0105-y
Authors
- Publisher:
- Nature Publishing Group
- Journal:
- British Journal of Cancer More from this journal
- Volume:
- 119
- Pages:
- 114–120
- Publication date:
- 2018-06-14
- Acceptance date:
- 2018-03-04
- DOI:
- EISSN:
-
1532-1827
- ISSN:
-
0007-0920
- Keywords:
- Pubs id:
-
pubs:831958
- UUID:
-
uuid:7e9b4183-a34c-43ee-8433-4263b92a8e5d
- Local pid:
-
pubs:831958
- Source identifiers:
-
831958
- Deposit date:
-
2018-04-04
Terms of use
- Copyright holder:
- Pirie et al
- Copyright date:
- 2018
- Notes:
- © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record