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Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors.

Abstract:

Most haematopoietic cells renew from adult haematopoietic stem cells (HSCs), however, macrophages in adult tissues can self-maintain independently of HSCs. Progenitors with macrophage potential in vitro have been described in the yolk sac before emergence of HSCs, and fetal macrophages can develop independently of Myb, a transcription factor required for HSC, and can persist in adult tissues. Nevertheless, the origin of adult macrophages and the qualitative and quantitative contributions of H...

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Publisher copy:
10.1038/nature13989

Authors


Perdiguero, EG More by this author
Klapproth, K More by this author
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Journal:
Nature
Publication date:
2014-12-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:7e6873af-fb00-4536-9cc7-e0e0d28023c7
Source identifiers:
493078
Local pid:
pubs:493078
Language:
English

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