Invariant natural killer T cells (iNKT cells) are involved in the host defense against microbial infection. Although it is known that iNKT cells recognize glycolipids presented by CD1d, how and where they encounter antigen in vivo remains unclear. Here we used multiphoton microscopy to visualize the dynamics and activation of iNKT cells in lymph nodes. After antigen administration, iNKT cells became confined in a CD1d-dependent manner in close proximity to subcapsular sinus CD169(+) macrophag...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes.
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record