- Abstract:
-
Invariant natural killer T cells (iNKT cells) are involved in the host defense against microbial infection. Although it is known that iNKT cells recognize glycolipids presented by CD1d, how and where they encounter antigen in vivo remains unclear. Here we used multiphoton microscopy to visualize the dynamics and activation of iNKT cells in lymph nodes. After antigen administration, iNKT cells became confined in a CD1d-dependent manner in close proximity to subcapsular sinus CD169(+) macrophag...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/ni.1853
-
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- Journal:
- Nature immunology
- Volume:
- 11
- Issue:
- 4
- Pages:
- 303-312
- Publication date:
- 2010-04-05
- DOI:
- EISSN:
-
1529-2916
- ISSN:
-
1529-2908
- URN:
-
uuid:7e5e3945-fc5b-4ab2-b9de-9e85afa7e19d
- Source identifiers:
-
51908
- Local pid:
- pubs:51908
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes.
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