Journal article

Enantioselective Copper(I)-Phosphoramidite Catalyzed Addition of Alkylzirconium Species to Acyclic Enones

Abstract:: Catalytic asymmetric conjugate addition reactions of alkylzirconium species to acyclic enones are reported. The alkylzirconium nucleophiles are generated in situ by hydrozirconation of alkenes with the Schwartz reagent. The reaction proceeds under mild and convenient conditions. A variety of functionalized nucleophiles can be used, and the method tolerates some variation in enone scope. The method uses a new chiral nonracemic phosphoramidite ligand in a complex with copper triflate.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Roth, P., & Fletcher, S. (2015). Enantioselective Copper(I)-Phosphoramidite Catalyzed Addition of Alkylzirconium Species to Acyclic Enones. Organic Letters, 17(4), 912–915.

MLA Style

Roth, P., and S. Fletcher. “Enantioselective Copper(I)-Phosphoramidite Catalyzed Addition of Alkylzirconium Species to Acyclic Enones.” Organic Letters, vol. 17, no. 4, American Chemical Society, 2015, pp. 912–15.

Chicago Style

Roth, P, and S Fletcher. 2015. “Enantioselective Copper(I)-Phosphoramidite Catalyzed Addition of Alkylzirconium Species to Acyclic Enones.” Organic Letters 17 (4): 912–15.
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Publisher copy:: 10.1021/acs.orglett.5b00021

Publication website:: http://pubs.acs.org/doi/abs/10.1021/acs.orglett.5b00021

Authors

+ Roth, P More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Role:: Author

+ Fletcher, S More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Role:: Author

+ Engineering and Physical Sciences Research Council More from this funder

Publisher:: American Chemical Society
Journal:: Organic Letters More from this journal
Volume:: 17
Issue:: 4
Pages:: 912–915
Publication date:: 2015-01-29
DOI:: 10.1021/acs.orglett.5b00021
EISSN:: 1523-7052
ISSN:: 1523-7060

Language:: English
UUID:: uuid:7e591d5d-7826-4e19-81fc-c164e69502a0
Deposit date:: 2015-09-18

Terms of use

Copyright date:: 2015

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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