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The genetic engineering of monoclonal antibodies.

Abstract:

A number of recent technological developments have greatly facilitated the genetic engineering of immunoglobulins. The use of PCR has permitted the variable regions to be rapidly cloned either from a specific hybridoma source or as a gene library from non-immunised cells. The conversion of the rodent antibody into a humanized version is now well established. To develop these antibodies for clinical use has required the development of high level expression systems. For the expression of large ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
Journal:
Journal of immunological methods
Volume:
168
Issue:
2
Pages:
149-165
Publication date:
1994-02-01
DOI:
EISSN:
1872-7905
ISSN:
0022-1759
Source identifiers:
171640
Language:
English
Keywords:
Pubs id:
pubs:171640
UUID:
uuid:7e26700d-6784-445e-8d7a-e56f711283ff
Local pid:
pubs:171640
Deposit date:
2012-12-19

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