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Journal article

Oncogenic K-Ras signals through epidermal growth factor receptor and wild-type H-Ras to promote radiation survival in pancreatic and colorectal carcinoma cells.

Abstract:

Pancreatic and colorectal carcinomas frequently express oncogenic/mutant K-Ras that contributes to both tumorigenesis and clinically observed resistance to radiation treatment. We have previously shown that farnesyltransferase inhibitors (FTI) radiosensitize many pancreatic and colorectal cancer cell lines that express oncogenic K-ras at doses that inhibit the prenylation and activation of H-Ras but not K-Ras. In the present study, we have examined the mechanism of FTI-mediated radiosensitiza...

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Publication status:
Published

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Publisher copy:
10.1593/neo.06823

Authors


Cengel, KA More by this author
Chandrasekaran, S More by this author
Maggiorella, L More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
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Journal:
Neoplasia (New York, N.Y.)
Volume:
9
Issue:
4
Pages:
341-348
Publication date:
2007-04-05
DOI:
EISSN:
1476-5586
ISSN:
1522-8002
URN:
uuid:7e006fb4-b74b-4989-be5d-128e755275de
Source identifiers:
118213
Local pid:
pubs:118213

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