Journal article
Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings.
- Abstract:
- An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
-
(Preview, Accepted manuscript, pdf, 57.1KB, Terms of use)
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(Preview, Accepted manuscript, pdf, 4.1MB, Terms of use)
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- Publisher copy:
- 10.1038/ng.3644
Authors
+ National Institute of Health
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- Funding agency for:
- Kariuki, S
- Grant:
- R01 AI099525-02
+ Biological Sciences Research Council
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- Funding agency for:
- Mather, A
- Grant:
- BB/M014088/1
+ Wellcome Trust
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- Funding agency for:
- Mather, A
- Feasey, N
- Heyderman, R
- Grant:
- BB/M014088/1
- 101113/Z/13/Z
- 101113/Z/13/Z
- 098051
+ Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence
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- Grant:
- ANR-10-LABX-62-IBEID
- Publisher:
- Nature Publishing Group
- Journal:
- Nature genetics More from this journal
- Volume:
- 48
- Issue:
- 10
- Pages:
- 1211-1217
- Publication date:
- 2016-08-22
- Acceptance date:
- 2016-07-15
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- Pmid:
-
27548315
- Language:
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English
- Keywords:
- Pubs id:
-
pubs:640529
- UUID:
-
uuid:7dfb5fb3-3d6a-4f97-bdd4-344a4925e086
- Local pid:
-
pubs:640529
- Source identifiers:
-
640529
- Deposit date:
-
2016-09-06
Terms of use
- Copyright holder:
- © 2016 Nature America, Inc All rights reserved
- Copyright date:
- 2016
- Notes:
- This is the author accepted manuscript following peer review version of the article. The final version is available online from Nature at: 10.1038/ng.3644. An erratum was published for this article on 30th March 2017 (49, 651) at [10.1038/ng0417-651c].
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