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Population pharmacokinetics of artemether–lumefantrine plus amodiaquine in patients with uncomplicated Plasmodium falciparum malaria

Abstract:

Aims: Resistance to the artemisinins and the artemisinin‐based combination therapy (ACT) partner drugs has developed in Southeast Asia, and artemisinin resistance has also emerged in eastern Africa. Triple ACTs (triple artemisinin‐based combination therapies, TACT), consisting of two partner drugs with different mechanisms of action and similar pharmacokinetic profiles, combined with an artemisinin derivative can help to delay or prevent artemisinin resistance and prolong the useful lifetime ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/bcp.70301

Authors

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Institution:
University of Oxford
Role:
Author
ORCID:
0000-0002-6429-3178
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Institution:
University of Oxford
Role:
Author
ORCID:
0000-0002-5322-912X
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Institution:
University of Oxford
Role:
Author
ORCID:
0000-0002-7040-5447
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Institution:
University of Oxford
Role:
Author
ORCID:
0000-0002-3218-2166
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Institution:
University of Oxford
Role:
Author
ORCID:
0000-0003-3197-9891


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Funder identifier:
https://ror.org/0456r8d26
More from this funder
Funder identifier:
https://ror.org/029chgv08


Publisher:
Wiley
Journal:
British Journal of Clinical Pharmacology More from this journal
Publication date:
2025-10-06
Acceptance date:
2025-09-10
DOI:
EISSN:
1365-2125
ISSN:
0306-5251


Language:
English
Keywords:
Pubs id:
2298740
Local pid:
pubs:2298740
Source identifiers:
3346672
Deposit date:
2025-10-07
ARK identifier:
This ORA record was generated from metadata provided by an external service. It has not been edited by the ORA Team.

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