Elimination of typhoid: possibility or pipe dream?

Journal article

Abstract:: The elimination of typhoid would have a substantial impact on the health of millions of people living in South and Southeast Asia and sub-Saharan Africa. Like many diseases before it, there are significant challenges to elimination, including access to safe drinking water and adequate sanitation practices, the availability of a vaccine, the identification and management of chronic carriers and the emergence of anti-microbial resistance. While provision of clean water and adequate sanitation must remain the ultimate goal, in the short term, required to cornerstone elimination in endemic areas, is an efficacious vaccine. Recent evidence of effectiveness with a tetanus-toxoid conjugate vaccine offers an opportunity for an immunogenic and safe vaccine able to be delivered to young children. Shown to be efficacious in Nepal, where infection is endemic, it may be a viable option in public health programmes moving towards elimination.

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Language:: English
Keywords:: tetanus-toxoid conjugated Vi polysaccharide vaccine

FFR

paratyphoid

typhoid

elimination
Pubs id:: 1125936
Local pid:: pubs:1125936
Deposit date:: 2020-08-20
ARK identifier:: ark:/29072/ora_7db73434133f4bcfb73cab1c91ad7fa2

Copyright holder:: Paediatrics and Child Health Division
Notes:: This is the accepted manuscript version of the article. The final version is available from Wiley at 10.1111/jpc.15088

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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