Therapeutic immunization for the control of HIV-1: where are we now?

Journal article

Highly active antiretroviral therapy (HAART) has transformed HIV-1 infection from an invariably fatal disease into a chronic infection requiring lifelong treatment. However, the challenges we still face are the urgent need to provide affordable sustainable therapy to the millions of infected individuals who live in resource-poor countries, and the limitations posed by serious drug toxicity and viral resistance associated with long-term therapy. Augmentation of HIV-specific immunity by therapeutic vaccination is a possible alternative to continuous HAART. In this review, progress in the development of therapeutic immunization strategies is discussed.

Authors: Dorrell, L

• Journal: International journal of STD and AIDS
• Volume: 17
• Issue: 7
• Pages: 436-442
• Publication date: 2006-07-01
• DOI: 10.1258/095646206777689035
• EISSN: 1758-1052
• ISSN: 0956-4624
• Language: English
• Keywords: Dendritic Cells; HIV-1; Immunization; AIDS Vaccines; Vaccines, DNA; HIV Infections; Animals; Humans