Journal article
Enhanced aqueous Suzuki-Miyaura coupling allows site-specific polypeptide 18F-labeling.
- Abstract:
-
The excesses of reagents used in protein chemistry are often incompatible with the reduced or even inverse stoichiometries used for efficient radiolabeling. Analysis and screening of aqueous Pd(0) ligand systems has revealed the importance of a guanidine core and the discovery of 1,1-dimethylguanidine as an enhanced ligand for aqueous Suzuki-Miyaura cross-coupling. This novel Pd catalyst system has now allowed the labeling of small molecules, peptides, and proteins with the fluorine-18 prosth...
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- Publication status:
- Published
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- Publisher copy:
- 10.1021/ja4049114
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Authors
Bibliographic Details
- Journal:
- Journal of the American Chemical Society
- Volume:
- 135
- Issue:
- 37
- Pages:
- 13612-13615
- Publication date:
- 2013-09-05
- DOI:
- EISSN:
-
1520-5126
- ISSN:
-
0002-7863
- Source identifiers:
-
429181
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:429181
- UUID:
-
uuid:7d64e323-d303-41e9-b0d3-5ca2ad014d4b
- Local pid:
- pubs:429181
- Deposit date:
- 2013-11-17
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- Copyright date:
- 2013
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