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Enhanced aqueous Suzuki-Miyaura coupling allows site-specific polypeptide 18F-labeling.

Abstract:

The excesses of reagents used in protein chemistry are often incompatible with the reduced or even inverse stoichiometries used for efficient radiolabeling. Analysis and screening of aqueous Pd(0) ligand systems has revealed the importance of a guanidine core and the discovery of 1,1-dimethylguanidine as an enhanced ligand for aqueous Suzuki-Miyaura cross-coupling. This novel Pd catalyst system has now allowed the labeling of small molecules, peptides, and proteins with the fluorine-18 prosth...

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Publication status:
Published

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Publisher copy:
10.1021/ja4049114

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
Journal of the American Chemical Society
Volume:
135
Issue:
37
Pages:
13612-13615
Publication date:
2013-09-05
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
URN:
uuid:7d64e323-d303-41e9-b0d3-5ca2ad014d4b
Source identifiers:
429181
Local pid:
pubs:429181

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