Effects of the competitive NMDA receptor antagonist CGP 37849 on performance of reference and working memory tasks by rats.

Journal article

The effects of the competitive NMDA receptor antagonist CGP 37849 (DL-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid) were tested in rats performing (1) a nonspatial working memory task, and (2) a reference memory task that was either partly or fully learnt. CGP 37849 attenuated accuracy in all three tests, suggesting that sensorimotor effects may obscure any drug effects on memory itself.

Authors: Deacon, R; Rawlins, J

• Publication status: Published
• Journal: European journal of pharmacology
• Volume: 280
• Issue: 2
• Pages: 239-242
• Publication date: 1995-07-01
• DOI: 10.1016/0014-2999(95)00255-j
• EISSN: 1879-0712
• ISSN: 0014-2999
• Language: English
• Keywords: 2-Amino-5-phosphonovalerate; Memory; Receptors, N-Methyl-D-Aspartate; Male; Psychomotor Performance; Maze Learning; Rats; Excitatory Amino Acid Antagonists; Memory, Short-Term; Animals; Discrimination (Psychology)