Effects of the competitive NMDA receptor antagonist CGP 37849 on performance of reference and working memory tasks by rats.
- The effects of the competitive NMDA receptor antagonist CGP 37849 (DL-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid) were tested in rats performing (1) a nonspatial working memory task, and (2) a reference memory task that was either partly or fully learnt. CGP 37849 attenuated accuracy in all three tests, suggesting that sensorimotor effects may obscure any drug effects on memory itself.
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